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Transforming Tomorrow, Today
News & Updates from the National Brain Tumor Society
April 2014
Spotlight
Tackling Clinical Trial Design From All Angles

Clinical trials are the last, crucial step for getting brain tumor treatments approved for patient use. Unfortunately, the success rate is low – only 34% of potential therapies make it through critical phase III trials. National Brain Tumor Society is committed to driving progress within the clinical trials process to increase the availability of new treatments.

Our Clinical Trial Endpoints Initiative is seeking to simplify earlier-stage trials, and thus accelerate the pace of potential brain tumor drug approvals. At the same time, we're exploring how to apply the concept of an "adaptive clinical trial" design to brain tumors. Adaptive clinical trials, particularly the I-SPY 2 model that has been delivering promising early results in the breast cancer field, offer hope to improve later-stage clinical trials.

Dr. Donald A. Berry, PhD, a leading biostatistician from MD Anderson Cancer Center, and one of the designers of the I-SPY 2 trial, has been supporting the National Brain Tumor Society in these early discussions. Dr. Berry notes that the advantages of the I-SPY 2 model include "the ability to stop assigning a therapy to... patients for whom it is offering no benefit... The design is great for patients in the trial, while at the same time accelerating drug development and making it more accurate."

We will share more insight into this topic in the coming months. In the meantime, we encourage you to explore the I-SPY 2 trial website to learn more.

From the Blog
March 27, 2014
Project Impact Gets to Work: Removing Barriers to Pediatric Cancer Treatments
The choice of when to push change in a broken system, "depends largely on timing, opportunity, and the leverage of the people initiating the change,[1]" according to popular theories in system change. Moreover, to achieve systems change leaders must, "bring people addressing parts of the problem around the same table," and by "...inviting new people [...]
Read More
March 31, 2014
Reasons to Run: Brooke Howitt E., M.D. Competes In The Boston Marathon to Fight Brain Tumors
On Patriots Day, April 21, 2014, runners from across the globe will compete in the annual Boston Marathon, one of the most renowned running competitions in the world. This year, the National Brain Tumor Society was fortunate enough to receive a number from the town of Newton, and we are excited to provide our number [...]
Read More
see all blog posts
Research in the News
New Approach to Killing Cancer

IBM Watson has Another Go At Helping Solve Brain Cancer Riddles

Tocagen Doses First Patient Intravenously in Clinical Trial of Selective Cancer Therapy, Toca 511 & Toca FC

Cortice Announces Enrollment of a Phase 2 Trial Evaluating TPI 287 Plus Avastin(R) for Treatment of Glioblastoma Previously Treated with Anti-Angiogenic Therapy

Clinical Trial For Glioblastoma Multiforme Therapy Enrolling by San Antonio-Based GenSpera

Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma
Upcoming Events
San Diego Brain Tumor Walk
San Diego, CA - Sunday, April 6, 2014
Delaware Brain Tumor Walk
Wilmington, DE - Saturday, April 26, 2014
Brain Tumor Awareness Month
May 1-31, 2014
Bay Area Brain Tumor Walk
San Francisco, CA - Saturday, May 3, 2014
Race for Hope Washington DC
Washington, DC - Sunday, May 4, 2014
Head to the Hill
Washington, DC - Monday, May 5 and 6, 2014
Boston Brain Tumor Ride
Waltham, MA - Sunday, May 18, 2014
Community Events
Mets Brain Tumor Awareness Night
New York, NY - Friday, April 25, 2014
Tom's Team
McKees Rocks, PA - Saturday, April 26, 2014
Phillies Brain Tumor Awareness Night
Philadelphia, PA - Saturday, May 17, 2014
Team Billy Ride and Walk for Research
Saratoga Springs, NY - Sunday, May 18, 2014
View All Events
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National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels.
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